Mini-Meet

About this Mini-Meet:

Title: Cellular and Molecular Plasticity in the Nervous System
Date: September 23, 2021
Time: 2pm CEST – 8am EDT – 10pm AEST
Venue: Virtual (Zoom)
Registration closes: September 23, 2021 – 1pm CEST – 7am EDT – 9pm AEST 

This mini-symposium will address cellular and molecular aspects that underly the exuberant plasticity that the nervous system displays both in a physiological context, but also under pathological conditions such as those seen after trauma, during aging and upon the development of neuropsychiatric disorders. The session will include talks highlighting the contribution of the main brain cellular types such as neurons, astrocytes and oligodendrocites to the plasticity as well as the maladaptive behavior that the nervous system shows after neurodegenerative stimuli and will discuss some of the recently described mechanisms supporting its participation into such complex system behavior. The session will also emphasize conserved and differential molecular mechanisms associated to a number of harmful stressors such as virus infection, neurodegenerative diseases and social stress.

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Chairs: 

  • Babette Fuss, Virginia Commonwealth Univeristy
  • Christian Gonzales-Billault, Universidad de Chile

Speakers: 

Britta Eickholt

Title: Essential role of the actin cytoskeleton during astrogliosis and scar formation

Representative manuscripts

Schiweck J, Murk K, Ledderose J, Münster-Wandowski A, Ornaghi M, Vida I, Eickholt BJ. Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking. Nat Commun. 2021 Mar 5;12(1):1490. doi: 10.1038/s41467-021-21662-x.

Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, Polyzou A, Ledderose J, van Diepen M, Holzhütter HG, Trimbuch T, Gimber N, Schmoranzer J, Lieberam I, Rosenmund C, Spahn C, Scheerer P, Szczepek M, Leondaritis G, Eickholt BJ. The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. Cell Rep. 2019 Nov 12;29(7):2028-2040.e8. doi: 10.1016/j.celrep.2019.10.039.

Nieuwenhuis B, Barber AC, Evans RS, Pearson CS, Fuchs J, MacQueen AR, van Erp S, Haenzi B, Hulshof LA, Osborne A, Conceicao R, Khatib TZ, Deshpande SS, Cave J, Ffrench-Constant C, Smith PD, Okkenhaug K, Eickholt BJ, Martin KR, Fawcett JW, Eva R. PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS. EMBO Mol Med. 2020 Aug 7;12(8):e11674. doi: 10.15252/emmm.201911674. Epub 2020 Jun 17.

Jia Liu

Title: Oligodendrocyte dysfunction and myelin plasticity  following chronic stress

Representative manuscripts

Liu J, Likhtik E, Sheren AD, Dennis-Tiwari TA, Casaccia P. White matter plasticity in anxiety: disruption of neural networks synchronization during threat-safety discrimination. Front Cell Neurosci 2020, 14, 587053. doi: 10.3389/fncel.2020.587053

Bonnefil V, Dietz K, Amatruda M, Wentling M, Aubry AV, Dupree JL, Temple G, Park HJ, Burghardt N, Casaccia P, Liu J. Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice. Elife 2019, 8, e40855. doi: 10.7554/eLife.4085.

Liu J, Dietz K, Hodes GE, Russo SJ, Casaccia P. Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress. Dev Neurobiol 2018, 78,152. doi: 10.1002/dneu.22533

Patricia Garcez

Title: Neurogenesis impairments in Congenital Zika Syndrome

Representative manuscripts:

Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK. Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep. 2020 Jan 27;10(1):1218. doi: 10.1038/s41598-020-57914-x.

Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016 May 13;352(6287):816-8. doi: 10.1126/science.aaf6116. Epub 2016 Apr 10.

Garcez PP, Diaz-Alonso J, Crespo-Enriquez I, Castro D, Bell D, Guillemot F. Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1. Nat Commun. 2015 Mar 10;6:6474. doi: 10.1038/ncomms7474.
PMID: 25753651 Free PMC article.

Tobias Merson

Title: Contribution of an adult neurogenic niche to oligodendrocyte regeneration

Representative manuscripts:

Xing YL, Chuang BHA, Poh J, Moradi K, Mitew S, Kilpatrick TJ, Osanai Y, Merson TD. A Novel Pharmacogenetic Model for Highly Efficient Ablation of Oligodendrocyte Progenitor Cells in the Adult Mouse CNS. bioRxiv 2021.05.13.443012. doi: 10.1101/2021.05.13.443012.

Mitew S, Gobius I, Fenlon LR, McDougall SJ, Hawkes D, Xing YL, Bujalka H, Gundlach AL, Richards LJ, Kilpatrick TJ, Merson TD, Emery B. Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner. Nat Commun 2018 Jan 22; 9:306. DOI: 10.1038/s41467-017-02719-2

Xing YL, Röth PT, Stratton JAS, Chuang BHA, Danne J, Ellis SL, Ng SW, Kilpatrick TJ, Merson TD. Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination. J Neurosci 2014 Oct 15; 34:14128. DOI: 10.1523/JNEUROSCI.3491-13.2014